nlg919

CAS 号：1402836-58-1 

英文名字：NLG-919 

质量标准：>98%,IDO抑制剂 

分子式：C18H22N2O

产品描述

NLG919是新型有效的indoleamine-2,3-dioxygenase (IDO)抑制剂，EC50为75 nM。

靶点

IDO

IDO

IC50

7 nM (Ki)

75 nM (EC50)

体外研究

NLG919 potently blocks IDO-induced T-cell suppression and restored robust T-cell responses with ED50 of 80 nM. Similarly, using IDO-expressing mouse DCs from tumor-draining lymph nodes, NLG919 abrogated IDO-induced suppression of antigen-specific T cells (OT-I) in vitro, with ED50 of 120 nM.

体内研究

In mice, a single oral administration of NLG919 reduces the concentration of plasma and tissue Kyn by ~ 50%. In mice bearing B16F10 tumors, NLG919 markedly enhances the antitumor responses of naive, resting pmel-1 cells to vaccination with cognate hgp100 peptide plus CpG-1826 in IFA.

溶解性

DMSO 56 mg/mL，水 <1 mg/mL，乙醇 56 mg/mL

稳定性

2年 -20°C粉状，6月-80°C溶于DMSO

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